Assay Detail
Functional
CHEMBL3767117
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodium activity against Plasmodium falciparum W2 by flow cytometry
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Trioxolane-Mediated Delivery of Mefloquine Limits Brain Exposure in a Mouse Model of Malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 8.46 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL580910 | — | — | 1 | 8.60 |
| CHEMBL172 | (S,R)-MEFLOQUINE | — | 1 | 8.60 |
| CHEMBL3763219 | — | — | 1 | 8.57 |
| CHEMBL3763644 | — | — | 1 | 8.52 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL580910 | — | EC50 | = | 2.5 | nM | 8.60 |
| CHEMBL172 | (S,R)-MEFLOQUINE | EC50 | = | 2.5 | nM | 8.60 |
| CHEMBL3763219 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3763644 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL269671 | ARTEMISININ | EC50 | = | 9.3 | nM | 8.03 |