Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3767149

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of IKKbeta (unknown origin) by TR-FRET assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Publication

Identification and characterization of potent, selective and metabolically stable IKKβ inhibitor.
Kim D, Kim YG, Seo JH, Shin KJ.
Bioorg Med Chem Lett (2016) 26 : 1120 -1123
PubMed 26826731 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 6.01 6.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2070413 1 6.46
CHEMBL3763391 1 6.22
CHEMBL3764354 1 6.19
CHEMBL3765499 1 6.10
CHEMBL3765155 1 6.10
CHEMBL3764369 1 6.09
CHEMBL3765759 1 6.09
CHEMBL3765189 1 6.08
CHEMBL3763983 1 6.08
CHEMBL3763572 1 6.07
CHEMBL3764955 1 6.05
CHEMBL3764998 1 6.02
CHEMBL3763698 1 5.95
CHEMBL3764641 1 5.68
CHEMBL3763439 1 5.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2070413 IC50 = 350.0 nM 6.46
CHEMBL3763391 IC50 = 600.0 nM 6.22
CHEMBL3764354 IC50 = 640.0 nM 6.19
CHEMBL3765499 IC50 = 790.0 nM 6.10
CHEMBL3765155 IC50 = 790.0 nM 6.10
CHEMBL3764369 IC50 = 820.0 nM 6.09
CHEMBL3765759 IC50 = 820.0 nM 6.09
CHEMBL3765189 IC50 = 840.0 nM 6.08
CHEMBL3763983 IC50 = 840.0 nM 6.08
CHEMBL3763572 IC50 = 850.0 nM 6.07
CHEMBL3764955 IC50 = 900.0 nM 6.05
CHEMBL3764998 IC50 = 960.0 nM 6.02
CHEMBL3763698 IC50 = 1130.0 nM 5.95
CHEMBL3764641 IC50 = 2100.0 nM 5.68
CHEMBL3763439 IC50 = 9880.0 nM 5.00