Assay Detail
Binding
CHEMBL3767207
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]methyllycaconitine from Sprague-Dawley rat brain alpha7* nAChR incubated for 2.5 hrs by liquid scintillation counting analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
New quinoline derivatives as nicotinic receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.51 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3764582 | — | — | 1 | 8.85 |
| CHEMBL2151572 | ENCENICLINE | 3.0 | 1 | 8.00 |
| CHEMBL2151442 | — | — | 1 | 7.96 |
| CHEMBL604798 | — | — | 1 | 7.87 |
| CHEMBL559478 | SSR180711 | 2.0 | 1 | 7.66 |
| CHEMBL177611 | PNU-282987 | — | 1 | 7.62 |
| CHEMBL3763220 | — | — | 1 | 7.02 |
| CHEMBL3764496 | — | — | 1 | 6.93 |
| CHEMBL3764445 | — | — | 1 | 6.61 |
| CHEMBL3765305 | — | — | 1 | 6.54 |
| CHEMBL3764287 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3764582 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL2151572 | ENCENICLINE | Ki | = | 9.98 | nM | 8.00 |
| CHEMBL2151442 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL604798 | — | Ki | = | 13.5 | nM | 7.87 |
| CHEMBL559478 | SSR180711 | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL177611 | PNU-282987 | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL3763220 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL3764496 | — | Ki | = | 117.0 | nM | 6.93 |
| CHEMBL3764445 | — | Ki | = | 248.0 | nM | 6.61 |
| CHEMBL3765305 | — | Ki | = | 287.0 | nM | 6.54 |
| CHEMBL3764287 | — | Ki | > | 1000.0 | nM | - |