Assay Detail
Binding
CHEMBL3767388
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human factor 12a using S-2302 as substrate assessed as para-nitroaniline release preincubated for 10 mins followed by substrate addition measured after 30 mins by HPLC-UV analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, evaluation and structure-activity relationship of new 3-carboxamide coumarins as FXIIa inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.87 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3765536 | — | — | 1 | 5.30 |
| CHEMBL3763881 | — | — | 1 | 5.16 |
| CHEMBL3763678 | — | — | 1 | 5.10 |
| CHEMBL493601 | — | — | 1 | 4.80 |
| CHEMBL3764790 | — | — | 1 | 4.47 |
| CHEMBL3763449 | — | — | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3765536 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3763881 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL3763678 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL493601 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL3764790 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL3763449 | — | IC50 | = | 41000.0 | nM | 4.39 |