Assay Detail
Binding
CHEMBL3767489
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Displacement of [3H]-vasopressin from human vasopressin 1a receptor expressed in HEK293 cells after 90 mins by microbeta 2 microplate-reader method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Flexible analogues of WAY-267,464: Synthesis and pharmacology at the human oxytocin and vasopressin 1a receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.78 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3763342 | — | — | 1 | 7.57 |
| CHEMBL3763951 | — | — | 1 | 7.21 |
| CHEMBL3763823 | — | — | 1 | 7.19 |
| CHEMBL3763217 | — | — | 1 | 6.89 |
| CHEMBL3763174 | — | — | 1 | 6.71 |
| CHEMBL3765689 | — | — | 1 | 6.61 |
| CHEMBL3765356 | — | — | 1 | 6.58 |
| CHEMBL3763620 | — | — | 1 | 6.39 |
| CHEMBL3765525 | — | — | 1 | 6.35 |
| CHEMBL3764572 | — | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3763342 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL3763951 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL3763823 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL3763217 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL3763174 | — | Ki | = | 195.0 | nM | 6.71 |
| CHEMBL3765689 | — | Ki | = | 248.0 | nM | 6.61 |
| CHEMBL3765356 | — | Ki | = | 266.0 | nM | 6.58 |
| CHEMBL3763620 | — | Ki | = | 409.0 | nM | 6.39 |
| CHEMBL3765525 | — | Ki | = | 449.0 | nM | 6.35 |
| CHEMBL3764572 | — | Ki | = | 466.0 | nM | 6.33 |