Assay Detail
Binding
CHEMBL3767549
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Porphyromonas gingivalis gamma carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Porphyromonas gingivalis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic bacterium Colwellia psychrerythraea.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 40 | 6.17 | 6.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 6.88 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 6.80 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 6.77 |
| CHEMBL6784 | — | — | 1 | 6.75 |
| CHEMBL6724 | — | — | 1 | 6.70 |
| CHEMBL2324869 | — | — | 1 | 6.66 |
| CHEMBL6919 | — | — | 1 | 6.65 |
| CHEMBL310671 | SACCHARIN | 3.0 | 1 | 6.56 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.49 |
| CHEMBL224292 | — | — | 1 | 6.49 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 6.46 |
| CHEMBL435 | HYDROCHLOROTHIAZIDE | 4.0 | 1 | 6.42 |
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 6.38 |
| CHEMBL328560 | SULTHIAME | 3.0 | 1 | 6.37 |
| CHEMBL265674 | — | — | 1 | 6.29 |
| CHEMBL414 | CARZENIDE | 2.0 | 1 | 6.25 |
| CHEMBL6753 | — | — | 1 | 6.22 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 6.21 |
| CHEMBL7092 | — | — | 1 | 6.18 |
| CHEMBL6853 | — | — | 1 | 6.17 |
| CHEMBL6633 | — | — | 1 | 6.16 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 6.16 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | — | 1 | 6.15 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 6.14 |
| CHEMBL73962 | BENZOLAMIDE | — | 1 | 6.13 |
| CHEMBL865 | VALDECOXIB | 4.0 | 1 | 6.12 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 6.05 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | 3.0 | 1 | 6.03 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 5.99 |
| CHEMBL266240 | — | — | 1 | 5.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL77517 | INDISULAM | Ki | = | 131.0 | nM | 6.88 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 157.0 | nM | 6.80 |
| CHEMBL118 | CELECOXIB | Ki | = | 169.0 | nM | 6.77 |
| CHEMBL6784 | — | Ki | = | 178.0 | nM | 6.75 |
| CHEMBL6724 | — | Ki | = | 201.0 | nM | 6.70 |
| CHEMBL2324869 | — | Ki | = | 218.0 | nM | 6.66 |
| CHEMBL6919 | — | Ki | = | 223.0 | nM | 6.65 |
| CHEMBL310671 | SACCHARIN | Ki | = | 273.0 | nM | 6.56 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 324.0 | nM | 6.49 |
| CHEMBL224292 | — | Ki | = | 326.0 | nM | 6.49 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 343.0 | nM | 6.46 |
| CHEMBL435 | HYDROCHLOROTHIAZIDE | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL26 | SULPIRIDE | Ki | = | 418.0 | nM | 6.38 |
| CHEMBL328560 | SULTHIAME | Ki | = | 424.0 | nM | 6.37 |
| CHEMBL265674 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL414 | CARZENIDE | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL6753 | — | Ki | = | 595.0 | nM | 6.22 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 613.0 | nM | 6.21 |
| CHEMBL7092 | — | Ki | = | 662.0 | nM | 6.18 |
| CHEMBL6853 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL6633 | — | Ki | = | 685.0 | nM | 6.16 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 685.0 | nM | 6.16 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | Ki | = | 711.0 | nM | 6.15 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 722.0 | nM | 6.14 |
| CHEMBL73962 | BENZOLAMIDE | Ki | = | 741.0 | nM | 6.13 |
| CHEMBL865 | VALDECOXIB | Ki | = | 755.0 | nM | 6.12 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 893.0 | nM | 6.05 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | Ki | = | 945.0 | nM | 6.03 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 1035.0 | nM | 5.99 |
| CHEMBL266240 | — | Ki | = | 1040.0 | nM | 5.98 |
| CHEMBL268439 | — | Ki | = | 1450.0 | nM | 5.84 |
| CHEMBL7146 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL2324864 | — | Ki | = | 3540.0 | nM | 5.45 |
| CHEMBL419 | MAFENIDE | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL7087 | — | Ki | = | 3840.0 | nM | 5.42 |
| CHEMBL269122 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL6852 | — | Ki | = | 4220.0 | nM | 5.38 |
| CHEMBL266026 | — | Ki | = | 4650.0 | nM | 5.33 |
| CHEMBL220492 | TOPIRAMATE | Ki | > | 100000.0 | nM | - |
| CHEMBL2324868 | — | Ki | > | 100000.0 | nM | - |