Assay Detail
Functional
CHEMBL3767553
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Cytotoxicity against human K562 cells after 72 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Dispirocyclopropyldehydrocostus lactone selectively inhibits acute myelogenous leukemia cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.89 | 7.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 7.23 |
| CHEMBL88985 | DEHYDROCOSTUSLACTONE | — | 1 | 5.28 |
| CHEMBL3765076 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL88985 | DEHYDROCOSTUSLACTONE | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL3765076 | — | IC50 | = | 7000.0 | nM | 5.16 |