Assay Detail
Binding
CHEMBL3767769
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human ERG channel
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.57 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL111201 | — | — | 1 | 6.66 |
| CHEMBL3764774 | — | — | 1 | 5.70 |
| CHEMBL3128178 | — | — | 1 | 5.21 |
| CHEMBL1684585 | — | — | 1 | 4.72 |
| CHEMBL3128188 | — | — | 1 | - |
| CHEMBL3764088 | — | — | 1 | - |
| CHEMBL3764950 | — | — | 1 | - |
| CHEMBL3763594 | — | — | 1 | - |
| CHEMBL3764592 | — | — | 1 | - |
| CHEMBL3765335 | — | — | 1 | - |
| CHEMBL3763998 | — | — | 1 | - |
| CHEMBL3763934 | — | — | 1 | - |
| CHEMBL2107826 | VIBEGRON | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL111201 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3764774 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3128178 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL1684585 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL3128188 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3764088 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3764950 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3763594 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3764592 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3765335 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3763998 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3763934 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2107826 | VIBEGRON | IC50 | > | 30000.0 | nM | - |