Assay Detail
Functional
CHEMBL3768082
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Cytotoxicity against human KM12 cells after 48 hrs by sulforhodamine B assay
6
Total Activities
2
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KM12 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
3,5-Bis(3-alkylaminomethyl-4-hydroxybenzylidene)-4-piperidones: A Novel Class of Potent Tumor-Selective Cytotoxins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.42 | 6.00 |
| TGI | 2 | - | - |
| CC50 | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3763325 | — | — | 3 | 6.00 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 3 | 4.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3763325 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL3763325 | — | TGI | = | 2190.0 | nM | - |
| CHEMBL185 | FLUOROURACIL | TGI | > | 1862000.0 | nM | - |
| CHEMBL3763325 | — | CC50 | = | 4680.0 | nM | - |
| CHEMBL185 | FLUOROURACIL | CC50 | > | 2512000.0 | nM | - |