Assay Detail
Binding
CHEMBL3768085
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of TAMRA-TRTK12 from recombinant rat calcium loaded S100-B by fluorescence polarization competition assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Small Molecule Inhibitors of Ca(2+)-S100B Reveal Two Protein Conformations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.60 | 5.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3764851 | — | — | 1 | 5.17 |
| CHEMBL3764285 | — | — | 1 | 4.74 |
| CHEMBL3765382 | — | — | 1 | 4.29 |
| CHEMBL289577 | — | — | 1 | 4.18 |
| CHEMBL3765054 | — | — | 1 | - |
| CHEMBL3765771 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3764851 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL3764285 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL3765382 | — | IC50 | = | 51100.0 | nM | 4.29 |
| CHEMBL289577 | — | IC50 | = | 66600.0 | nM | 4.18 |
| CHEMBL3765054 | — | IC50 | = | 981700.0 | nM | - |
| CHEMBL3765771 | — | IC50 | = | 2222100.0 | nM | - |