Assay Detail
Binding
CHEMBL3768086
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Displacement of TAMRA-TRTK12 from recombinant rat calcium loaded S100-B by Nikolovska-Cleska analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Small Molecule Inhibitors of Ca(2+)-S100B Reveal Two Protein Conformations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 5.34 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3764851 | — | — | 1 | 6.30 |
| CHEMBL3764285 | — | — | 1 | 5.80 |
| CHEMBL3765382 | — | — | 1 | 5.34 |
| CHEMBL289577 | — | — | 1 | 5.22 |
| CHEMBL3765054 | — | — | 1 | 4.05 |
| CHEMBL3765771 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3764851 | — | Kd | = | 500.0 | nM | 6.30 |
| CHEMBL3764285 | — | Kd | = | 1600.0 | nM | 5.80 |
| CHEMBL3765382 | — | Kd | = | 4600.0 | nM | 5.34 |
| CHEMBL289577 | — | Kd | = | 6000.0 | nM | 5.22 |
| CHEMBL3765054 | — | Kd | = | 89500.0 | nM | 4.05 |
| CHEMBL3765771 | — | Kd | = | 202600.0 | nM | - |