Assay Detail
Binding
CHEMBL3768099
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Inhibition of MANT-uracil binding to Caenorhabditis elegans CRBN (delta 1 to 15) by FRET assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Caenorhabditis elegans |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A FRET-Based Assay for the Identification and Characterization of Cereblon Ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.73 | 5.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275661 | SUCCINIMIDE | -1.0 | 1 | 5.17 |
| CHEMBL468 | THALIDOMIDE | 4.0 | 1 | 4.73 |
| CHEMBL3763941 | — | — | 1 | 4.30 |
| CHEMBL25028 | DIMETHYL SULFONE | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275661 | SUCCINIMIDE | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL468 | THALIDOMIDE | IC50 | = | 18600.0 | nM | 4.73 |
| CHEMBL3763941 | — | IC50 | = | 50600.0 | nM | 4.30 |
| CHEMBL25028 | DIMETHYL SULFONE | IC50 | = | 361000000.0 | nM | - |