Assay Detail
ADMET
CHEMBL3768348
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Cytotoxicity against human PBL cells after 72 hrs by MTT assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | PBL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel 4-phenoxy-6,7-disubstituted quinolines possessing (thio)semicarbazones as c-Met kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 4.43 | 4.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3764184 | — | — | 1 | 4.76 |
| CHEMBL3765572 | — | — | 1 | 4.64 |
| CHEMBL3765283 | — | — | 1 | 4.59 |
| CHEMBL3764320 | — | — | 1 | 4.58 |
| CHEMBL3764060 | — | — | 1 | 4.47 |
| CHEMBL3763970 | — | — | 1 | 4.44 |
| CHEMBL3765124 | — | — | 1 | 4.16 |
| CHEMBL3764158 | — | — | 1 | 4.11 |
| CHEMBL3763886 | — | — | 1 | 4.10 |
| CHEMBL3764971 | — | — | 1 | - |
| CHEMBL3764279 | — | — | 1 | - |
| CHEMBL3765043 | — | — | 1 | - |
| CHEMBL3763874 | — | — | 1 | - |
| CHEMBL3764494 | — | — | 1 | - |
| CHEMBL3765241 | — | — | 1 | - |
| CHEMBL3763852 | — | — | 1 | - |
| CHEMBL3764610 | — | — | 1 | - |
| CHEMBL3765825 | — | — | 1 | - |
| CHEMBL3764241 | — | — | 1 | - |
| CHEMBL3763783 | — | — | 1 | - |
| CHEMBL591429 | PAC-1 | 1.0 | 1 | - |
| CHEMBL1230609 | FORETINIB | 2.0 | 1 | - |
| CHEMBL3764523 | — | — | 1 | - |
| CHEMBL3764782 | — | — | 1 | - |
| CHEMBL3764722 | — | — | 1 | - |
| CHEMBL3764198 | — | — | 1 | - |
| CHEMBL3764780 | — | — | 1 | - |
| CHEMBL3763986 | — | — | 1 | - |
| CHEMBL3765709 | — | — | 1 | - |
| CHEMBL3763835 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3764184 | — | IC50 | = | 17250.0 | nM | 4.76 |
| CHEMBL3765572 | — | IC50 | = | 23020.0 | nM | 4.64 |
| CHEMBL3765283 | — | IC50 | = | 25470.0 | nM | 4.59 |
| CHEMBL3764320 | — | IC50 | = | 26480.0 | nM | 4.58 |
| CHEMBL3764060 | — | IC50 | = | 34120.0 | nM | 4.47 |
| CHEMBL3763970 | — | IC50 | = | 36430.0 | nM | 4.44 |
| CHEMBL3765124 | — | IC50 | = | 68680.0 | nM | 4.16 |
| CHEMBL3764158 | — | IC50 | = | 78360.0 | nM | 4.11 |
| CHEMBL3763886 | — | IC50 | = | 79490.0 | nM | 4.10 |
| CHEMBL3764279 | — | IC50 | = | 106910.0 | nM | - |
| CHEMBL3765600 | — | IC50 | - | — | - | |
| CHEMBL3765043 | — | IC50 | - | — | - | |
| CHEMBL3763874 | — | IC50 | - | — | - | |
| CHEMBL3764494 | — | IC50 | - | — | - | |
| CHEMBL3765241 | — | IC50 | - | — | - | |
| CHEMBL3763852 | — | IC50 | - | — | - | |
| CHEMBL3764610 | — | IC50 | - | — | - | |
| CHEMBL3765825 | — | IC50 | - | — | - | |
| CHEMBL3764241 | — | IC50 | = | 125560.0 | nM | - |
| CHEMBL3764550 | — | IC50 | - | — | - | |
| CHEMBL3763544 | — | IC50 | - | — | - | |
| CHEMBL3764971 | — | IC50 | - | — | - | |
| CHEMBL3763783 | — | IC50 | - | — | - | |
| CHEMBL591429 | PAC-1 | IC50 | = | 123810.0 | nM | - |
| CHEMBL1230609 | FORETINIB | IC50 | - | — | - | |
| CHEMBL3764523 | — | IC50 | - | — | - | |
| CHEMBL3764782 | — | IC50 | - | — | - | |
| CHEMBL3764722 | — | IC50 | - | — | - | |
| CHEMBL3764198 | — | IC50 | - | — | - | |
| CHEMBL3764780 | — | IC50 | - | — | - | |
| CHEMBL3763986 | — | IC50 | - | — | - | |
| CHEMBL3765709 | — | IC50 | - | — | - | |
| CHEMBL3763835 | — | IC50 | - | — | - |