Assay Detail
Functional
CHEMBL3768478
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 8.68 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3763934 | — | — | 1 | 9.21 |
| CHEMBL1684585 | — | — | 1 | 9.05 |
| CHEMBL2107826 | VIBEGRON | 4.0 | 1 | 8.96 |
| CHEMBL3128178 | — | — | 1 | 8.85 |
| CHEMBL3764774 | — | — | 1 | 8.77 |
| CHEMBL111201 | — | — | 1 | 8.70 |
| CHEMBL3763594 | — | — | 1 | 8.66 |
| CHEMBL3763998 | — | — | 1 | 8.59 |
| CHEMBL3765335 | — | — | 1 | 8.57 |
| CHEMBL3128188 | — | — | 1 | 8.43 |
| CHEMBL3764950 | — | — | 1 | 8.41 |
| CHEMBL3764592 | — | — | 1 | 8.37 |
| CHEMBL3764088 | — | — | 1 | 8.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3763934 | — | EC50 | = | 0.62 | nM | 9.21 |
| CHEMBL1684585 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL2107826 | VIBEGRON | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3128178 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3764774 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL111201 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3763594 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3763998 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL3765335 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3128188 | — | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL3764950 | — | EC50 | = | 3.9 | nM | 8.41 |
| CHEMBL3764592 | — | EC50 | = | 4.3 | nM | 8.37 |
| CHEMBL3764088 | — | EC50 | = | 4.8 | nM | 8.32 |