Assay Detail
Functional
CHEMBL3769004
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Antiproliferative activity against mouse L1210 cells assessed as cell survival after 48 hrs by coulter counter analysis
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
3,5-Bis(3-alkylaminomethyl-4-hydroxybenzylidene)-4-piperidones: A Novel Class of Potent Tumor-Selective Cytotoxins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.36 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3764662 | — | — | 1 | 6.11 |
| CHEMBL3764683 | — | — | 1 | 6.06 |
| CHEMBL3763807 | — | — | 1 | 5.92 |
| CHEMBL3763325 | — | — | 1 | 5.89 |
| CHEMBL3763402 | — | — | 1 | 5.70 |
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 5.67 |
| CHEMBL129134 | — | — | 1 | 5.11 |
| CHEMBL2391734 | — | — | 1 | 5.11 |
| CHEMBL3764362 | — | — | 1 | 5.11 |
| CHEMBL154716 | — | — | 1 | 5.10 |
| CHEMBL482409 | — | — | 1 | 4.97 |
| CHEMBL2391731 | — | — | 1 | 4.87 |
| CHEMBL2036329 | — | — | 1 | 4.01 |
| CHEMBL3764404 | — | — | 1 | - |
| CHEMBL3765303 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3764662 | — | IC50 | = | 774.0 | nM | 6.11 |
| CHEMBL3764683 | — | IC50 | = | 867.0 | nM | 6.06 |
| CHEMBL3763807 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL3763325 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL3763402 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL852 | MELPHALAN | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL129134 | — | IC50 | = | 7740.0 | nM | 5.11 |
| CHEMBL2391734 | — | IC50 | = | 7840.0 | nM | 5.11 |
| CHEMBL3764362 | — | IC50 | = | 7780.0 | nM | 5.11 |
| CHEMBL154716 | — | IC50 | = | 7960.0 | nM | 5.10 |
| CHEMBL482409 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL2391731 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL2036329 | — | IC50 | = | 96800.0 | nM | 4.01 |
| CHEMBL3764404 | — | IC50 | = | 165000.0 | nM | - |
| CHEMBL3765303 | — | IC50 | > | 500000.0 | nM | - |