Assay Detail
Binding
CHEMBL3769180
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine brain tubulin polymerization preincubated for 15 mins by spectrophotometric analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.67 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2022434 | — | — | 1 | 6.21 |
| CHEMBL217041 | — | — | 1 | 5.96 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.92 |
| CHEMBL330407 | — | — | 1 | 5.92 |
| CHEMBL3087395 | — | — | 1 | 5.89 |
| CHEMBL256278 | — | — | 1 | 5.82 |
| CHEMBL3763412 | — | — | 1 | 5.64 |
| CHEMBL3764667 | — | — | 1 | 5.60 |
| CHEMBL585539 | — | — | 1 | 4.89 |
| CHEMBL572284 | OMBRABULIN | 3.0 | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2022434 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL217041 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL330407 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3087395 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL256278 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3763412 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3764667 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL585539 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL572284 | OMBRABULIN | IC50 | = | 14000.0 | nM | 4.85 |