Assay Detail
Binding
CHEMBL3769290
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Inhibition of Mycobacterium tuberculosis leucyl-tRNA synthetase assessed as reduction of [14C]-L-leucine ligation to tRNA incubated for 5 mins by scintillation counting method in presence of ATP
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of potent anti-tuberculosis agents targeting leucyl-tRNA synthetase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 4.98 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3764310 | — | — | 1 | 5.64 |
| CHEMBL3764493 | — | — | 1 | 5.34 |
| CHEMBL3763921 | — | — | 1 | 5.22 |
| CHEMBL3765025 | — | — | 1 | 5.10 |
| CHEMBL2436531 | — | — | 1 | 4.94 |
| CHEMBL3765180 | — | — | 1 | 4.80 |
| CHEMBL3764864 | — | — | 1 | 4.71 |
| CHEMBL3199451 | — | — | 1 | 4.70 |
| CHEMBL3763231 | — | — | 1 | 4.70 |
| CHEMBL1320974 | — | — | 1 | 4.65 |
| CHEMBL3764428 | — | — | 1 | - |
| CHEMBL3763642 | — | — | 1 | - |
| CHEMBL3763922 | — | — | 1 | - |
| CHEMBL3763960 | — | — | 1 | - |
| CHEMBL3763240 | — | — | 1 | - |
| CHEMBL3763212 | — | — | 1 | - |
| CHEMBL3765018 | — | — | 1 | - |
| CHEMBL3764700 | — | — | 1 | - |
| CHEMBL3763938 | — | — | 1 | - |
| CHEMBL3765282 | — | — | 1 | - |
| CHEMBL3765458 | — | — | 1 | - |
| CHEMBL3765364 | — | — | 1 | - |
| CHEMBL3764842 | — | — | 1 | - |
| CHEMBL3763977 | — | — | 1 | - |
| CHEMBL3765792 | — | — | 1 | - |
| CHEMBL3190031 | — | — | 1 | - |
| CHEMBL3764109 | — | — | 1 | - |
| CHEMBL3763845 | — | — | 1 | - |
| CHEMBL3764304 | — | — | 1 | - |
| CHEMBL3764978 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3764310 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL3764493 | — | IC50 | = | 4540.0 | nM | 5.34 |
| CHEMBL3763921 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3765025 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL2436531 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL3765180 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL3764864 | — | IC50 | = | 19300.0 | nM | 4.71 |
| CHEMBL3199451 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3763231 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1320974 | — | IC50 | = | 22200.0 | nM | 4.65 |
| CHEMBL3763642 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3763922 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3763960 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3763240 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3763212 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3765018 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3764700 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3763938 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3765282 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3763208 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3764492 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3764428 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3765458 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3765364 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3764842 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3763977 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3765792 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3190031 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3764109 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3763845 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3764304 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3764978 | — | IC50 | > | 50000.0 | nM | - |