Assay Detail
Binding
CHEMBL3769291
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human leucyl-tRNA synthetase assessed as reduction of [14C]-L-leucine ligation to tRNA incubated for 5 mins by scintillation counting method in presence of ATP
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent anti-tuberculosis agents targeting leucyl-tRNA synthetase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.54 | 4.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3764310 | — | — | 1 | 4.73 |
| CHEMBL3764493 | — | — | 1 | 4.56 |
| CHEMBL3765025 | — | — | 1 | 4.34 |
| CHEMBL2436531 | — | — | 1 | - |
| CHEMBL3763921 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3764310 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL3764493 | — | IC50 | = | 27600.0 | nM | 4.56 |
| CHEMBL3765025 | — | IC50 | = | 45800.0 | nM | 4.34 |
| CHEMBL2436531 | — | IC50 | = | 116300.0 | nM | - |
| CHEMBL3763921 | — | IC50 | = | 115700.0 | nM | - |