Assay Detail
Functional
CHEMBL3771983
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human BJAB cells after 24 hrs by CASY cell counting method
14
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BJAB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of indole-derived allocolchicine congeners exhibiting pronounced anti-proliferative and apoptosis-inducing properties
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.22 | 9.00 |
| Activity | 7 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3770157 | — | — | 2 | 9.00 |
| CHEMBL3770660 | — | — | 2 | 8.00 |
| CHEMBL3770528 | — | — | 2 | 8.00 |
| CHEMBL107 | COLCHICINE | 4.0 | 2 | 7.70 |
| CHEMBL3770573 | — | — | 2 | 6.30 |
| CHEMBL3770904 | — | — | 2 | 4.30 |
| CHEMBL3770176 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3770157 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3770660 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3770528 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL107 | COLCHICINE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3770573 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3770904 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL3770176 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL107 | COLCHICINE | Activity | - | — | - | |
| CHEMBL3770157 | — | Activity | - | — | - | |
| CHEMBL3770528 | — | Activity | - | — | - | |
| CHEMBL3770660 | — | Activity | - | — | - | |
| CHEMBL3770904 | — | Activity | - | — | - | |
| CHEMBL3770573 | — | Activity | - | — | - | |
| CHEMBL3770176 | — | Activity | - | — | - |