Assay Detail
Binding
CHEMBL3771989
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of sheep tubulin polymerization by fluorescence based assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of indole-derived allocolchicine congeners exhibiting pronounced anti-proliferative and apoptosis-inducing properties
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.72 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 7.05 |
| CHEMBL3770660 | — | — | 1 | 6.90 |
| CHEMBL3771359 | — | — | 1 | 6.64 |
| CHEMBL3771272 | — | — | 1 | 6.58 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3770660 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL3771359 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL3771272 | — | IC50 | = | 264.0 | nM | 6.58 |
| CHEMBL107 | COLCHICINE | IC50 | = | 375.0 | nM | 6.43 |