Assay Detail
Binding
CHEMBL3772018
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to OX2R (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Orexin Receptor Antagonists: New Therapeutic Agents for the Treatment of Insomnia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.53 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3770503 | — | — | 1 | 10.00 |
| CHEMBL2107822 | FILOREXANT | 2.0 | 1 | 9.52 |
| CHEMBL3597953 | — | — | 1 | 9.00 |
| CHEMBL3771050 | — | — | 1 | 8.40 |
| CHEMBL3394825 | — | — | 1 | 7.80 |
| CHEMBL3769978 | — | — | 1 | 7.66 |
| CHEMBL3597954 | — | — | 1 | 7.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3770503 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL2107822 | FILOREXANT | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL3597953 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL3771050 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL3394825 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL3769978 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL3597954 | — | Ki | = | 44.0 | nM | 7.36 |