Assay Detail
Binding
CHEMBL3772019
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to OX1R (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Orexin Receptor Antagonists: New Therapeutic Agents for the Treatment of Insomnia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.49 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3597953 | — | — | 1 | 10.22 |
| CHEMBL3770503 | — | — | 1 | 9.52 |
| CHEMBL2107822 | FILOREXANT | 2.0 | 1 | 8.66 |
| CHEMBL3771050 | — | — | 1 | 8.10 |
| CHEMBL3394825 | — | — | 1 | 7.82 |
| CHEMBL3597954 | — | — | 1 | 7.64 |
| CHEMBL3769978 | — | — | 1 | 7.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3597953 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL3770503 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL2107822 | FILOREXANT | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL3771050 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL3394825 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL3597954 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL3769978 | — | Ki | = | 34.0 | nM | 7.47 |