Assay Detail

CHEMBL3772095

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of ROCK2 (unknown origin) using STK2 as substrate after 1 hr

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Rho-associated protein kinase 2 (CHEMBL2973) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Rho-associated protein kinase 2 (CHEMBL2973) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Rho-associated protein kinase 2

CHEMBL2973

Anchored from Assay target.

Protein identity Rho-associated protein kinase 2

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Rho-associated protein kinase 2 (CHEMBL2973) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions.

Donegan RK, Lieberman RL.
J Med Chem (2016) 59 : 788 -809
PubMed 26356532 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.52	8.52

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL521179	SR-3677	—	1	8.52

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL521179	SR-3677	IC50	=	3.0	nM	8.52