Assay Detail
Binding
CHEMBL3772097
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Inhibition of ROCK2 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.77 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3770836 | — | — | 1 | 8.96 |
| CHEMBL3770730 | — | — | 1 | 8.82 |
| CHEMBL3426621 | RIPASUDIL | 3.0 | 1 | 7.72 |
| CHEMBL559147 | Y-27632 | — | 1 | 6.85 |
| CHEMBL38380 | FASUDIL | 3.0 | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3770836 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3770730 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3426621 | RIPASUDIL | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL559147 | Y-27632 | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL38380 | FASUDIL | IC50 | = | 320.0 | nM | 6.50 |