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Assay Detail

CHEMBL3772183

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of MAOB (unknown origin)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] B (CHEMBL2039)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Acetophenone derivatives: novel and potent small molecule inhibitors of monoamine oxidase B
Wang Z, Li X, Xu W, Li F, Wang J, Kong L, Wang X
Medchemcomm (2015) 6 : 2146 -2157
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 8.23 8.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL325761 1 8.96
CHEMBL2391742 1 8.85
CHEMBL1945153 1 8.70
CHEMBL3770377 1 8.54
CHEMBL2062879 1 8.40
CHEMBL3288299 1 8.35
CHEMBL2062882 1 8.24
CHEMBL3770875 1 8.10
CHEMBL1682819 1 8.07
CHEMBL45069 1 7.96
CHEMBL396778 SAFINAMIDE 4.0 1 6.35

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL325761 IC50 = 1.1 nM 8.96
CHEMBL2391742 IC50 = 1.4 nM 8.85
CHEMBL1945153 IC50 = 2.0 nM 8.70
CHEMBL3770377 IC50 = 2.9 nM 8.54
CHEMBL2062879 IC50 = 4.0 nM 8.40
CHEMBL3288299 IC50 = 4.5 nM 8.35
CHEMBL2062882 IC50 = 5.7 nM 8.24
CHEMBL3770875 IC50 = 8.0 nM 8.10
CHEMBL1682819 IC50 = 8.6 nM 8.07
CHEMBL45069 IC50 = 11.0 nM 7.96
CHEMBL396778 SAFINAMIDE IC50 = 450.0 nM 6.35