Assay Detail
Binding
CHEMBL3772327
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Binding affinity to recombinant N-terminal GST-tagged HIV1 NL4-3 capsid C-terminal domain (146 to 231 residues) incubated for 2 hrs by alphascreen assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Structural capsid protein (CHEMBL2366504) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Specific Inhibitors of HIV Capsid Assembly Binding to the C-Terminal Domain of the Capsid Protein: Evaluation of 2-Arylquinazolines as Potential Antiviral Compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 4.69 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3770536 | — | — | 1 | 5.52 |
| CHEMBL3769666 | — | — | 1 | 5.40 |
| CHEMBL3770825 | — | — | 1 | 5.10 |
| CHEMBL3770712 | — | — | 1 | 5.05 |
| CHEMBL3769713 | — | — | 1 | 4.85 |
| CHEMBL3770260 | — | — | 1 | 4.85 |
| CHEMBL3770941 | — | — | 1 | 4.68 |
| CHEMBL3770798 | — | — | 1 | 4.52 |
| CHEMBL3770162 | — | — | 1 | 4.43 |
| CHEMBL3770739 | — | — | 1 | 4.43 |
| CHEMBL1420370 | — | — | 1 | 4.33 |
| CHEMBL3769466 | — | — | 1 | 4.20 |
| CHEMBL1622298 | — | — | 1 | 4.17 |
| CHEMBL3770103 | — | — | 1 | 4.10 |
| CHEMBL3769718 | — | — | 1 | - |
| CHEMBL3769471 | — | — | 1 | - |
| CHEMBL3769554 | — | — | 1 | - |
| CHEMBL3771171 | — | — | 1 | - |
| CHEMBL3770841 | — | — | 1 | - |
| CHEMBL3770181 | — | — | 1 | - |
| CHEMBL3769776 | — | — | 1 | - |
| CHEMBL3771100 | — | — | 1 | - |
| CHEMBL3769485 | — | — | 1 | - |
| CHEMBL3770605 | — | — | 1 | - |
| CHEMBL3771220 | — | — | 1 | - |
| CHEMBL3770220 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3770536 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3769666 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3770825 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3770712 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL3769713 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3770260 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3770941 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL3770798 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL3770162 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL3770739 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL1420370 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL3769466 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL1622298 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL3770103 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL3769718 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3769471 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3769554 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3771171 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3770841 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3770181 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3769776 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3771100 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3769485 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3770605 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3771220 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3770220 | — | IC50 | > | 100000.0 | nM | - |