Assay Detail
Functional
CHEMBL3772420
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Antiproliferative activity against human MCF7 cells after 96 hrs by propidium iodide-based monolayer assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel cis-selective and non-epimerisable C3 hydroxy azapodophyllotoxins targeting microtubules in cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.18 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL452231 | TENIPOSIDE | 4.0 | 1 | 6.90 |
| CHEMBL3769893 | — | — | 1 | 6.68 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 6.64 |
| CHEMBL3771178 | — | — | 1 | 6.54 |
| CHEMBL3770801 | — | — | 1 | 6.45 |
| CHEMBL3769803 | — | — | 1 | 6.40 |
| CHEMBL3771147 | — | — | 1 | 6.37 |
| CHEMBL3770232 | — | — | 1 | 6.33 |
| CHEMBL3770607 | — | — | 1 | 6.32 |
| CHEMBL3769910 | — | — | 1 | 6.23 |
| CHEMBL3769784 | — | — | 1 | 6.19 |
| CHEMBL3771084 | — | — | 1 | 6.19 |
| CHEMBL3770737 | — | — | 1 | 6.08 |
| CHEMBL3770476 | — | — | 1 | 6.07 |
| CHEMBL3770707 | — | — | 1 | 6.04 |
| CHEMBL3770784 | — | — | 1 | 6.04 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.90 |
| CHEMBL3769435 | — | — | 1 | 5.64 |
| CHEMBL3769813 | — | — | 1 | 5.48 |
| CHEMBL3771249 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL452231 | TENIPOSIDE | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL3769893 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL61 | PODOFILOX | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3771178 | — | IC50 | = | 288.0 | nM | 6.54 |
| CHEMBL3770801 | — | IC50 | = | 355.0 | nM | 6.45 |
| CHEMBL3769803 | — | IC50 | = | 396.0 | nM | 6.40 |
| CHEMBL3771147 | — | IC50 | = | 424.0 | nM | 6.37 |
| CHEMBL3770232 | — | IC50 | = | 466.0 | nM | 6.33 |
| CHEMBL3770607 | — | IC50 | = | 475.0 | nM | 6.32 |
| CHEMBL3769910 | — | IC50 | = | 589.0 | nM | 6.23 |
| CHEMBL3769784 | — | IC50 | = | 643.0 | nM | 6.19 |
| CHEMBL3771084 | — | IC50 | = | 648.0 | nM | 6.19 |
| CHEMBL3770737 | — | IC50 | = | 825.0 | nM | 6.08 |
| CHEMBL3770476 | — | IC50 | = | 857.0 | nM | 6.07 |
| CHEMBL3770707 | — | IC50 | = | 901.0 | nM | 6.04 |
| CHEMBL3770784 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 1264.0 | nM | 5.90 |
| CHEMBL3769435 | — | IC50 | = | 2295.0 | nM | 5.64 |
| CHEMBL3769813 | — | IC50 | = | 3307.0 | nM | 5.48 |
| CHEMBL3771249 | — | IC50 | = | 7250.0 | nM | 5.14 |