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Assay Detail

CHEMBL3772425

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antischistosomal activity against juvenile stage of Schistosoma japonicum after 72 hrs by microscopy
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Schistosoma japonicum
Tissue Juvenile stage
Confidence 1 — Organism
Curated By Autocuration

Target

Schistosoma japonicum (CHEMBL612644)
Type ORGANISM
Organism Schistosoma japonicum

Publication

Antischistosomal activity of N,N'-arylurea analogs against Schistosoma japonicum.
Yao H, Liu F, Chen J, Li Y, Cui J, Qiao C.
Bioorg Med Chem Lett (2016) 26 : 1386 -1390
PubMed 26856921 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.03 5.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3770729 1 5.60
CHEMBL530543 1 5.55
CHEMBL3770083 1 5.37
CHEMBL10835 1 5.36
CHEMBL3769525 1 5.33
CHEMBL3770138 1 5.16
CHEMBL3771028 1 5.02
CHEMBL510619 1 5.00
CHEMBL3770611 1 4.95
CHEMBL1688054 1 4.90
CHEMBL3770583 1 4.89
CHEMBL3770521 1 4.72
CHEMBL3769867 1 4.65
CHEMBL104176 1 4.65
CHEMBL3770288 1 4.65
CHEMBL3770629 1 4.65

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3770729 IC50 = 2500.0 nM 5.60
CHEMBL530543 IC50 = 2800.0 nM 5.55
CHEMBL3770083 IC50 = 4300.0 nM 5.37
CHEMBL10835 IC50 = 4400.0 nM 5.36
CHEMBL3769525 IC50 = 4700.0 nM 5.33
CHEMBL3770138 IC50 = 7000.0 nM 5.16
CHEMBL3771028 IC50 = 9600.0 nM 5.02
CHEMBL510619 IC50 = 10100.0 nM 5.00
CHEMBL3770611 IC50 = 11300.0 nM 4.95
CHEMBL1688054 IC50 = 12700.0 nM 4.90
CHEMBL3770583 IC50 = 12800.0 nM 4.89
CHEMBL3770521 IC50 = 19000.0 nM 4.72
CHEMBL3769867 IC50 = 22600.0 nM 4.65
CHEMBL104176 IC50 = 22600.0 nM 4.65
CHEMBL3770288 IC50 = 22600.0 nM 4.65
CHEMBL3770629 IC50 = 22600.0 nM 4.65