Assay Detail
Functional
CHEMBL3772952
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Agonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysis
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel Adenosine Receptor Agonists That Exhibit Subtype Selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.01 | 9.31 |
| pIC50 | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL464859 | NECA | — | 1 | 9.31 |
| CHEMBL477 | ADENOSINE | 4.0 | 1 | 8.94 |
| CHEMBL3770310 | — | — | 1 | 8.64 |
| CHEMBL284969 | — | — | 1 | 7.95 |
| CHEMBL116903 | — | — | 1 | 7.56 |
| CHEMBL3769641 | — | — | 1 | 7.10 |
| CHEMBL3770679 | — | — | 1 | 6.57 |
| CHEMBL3771290 | — | — | 1 | - |
| CHEMBL3771208 | — | — | 1 | - |
| CHEMBL3770664 | — | — | 1 | - |
| CHEMBL3771184 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL464859 | NECA | IC50 | = | 0.4898 | nM | 9.31 |
| CHEMBL477 | ADENOSINE | IC50 | = | 1.148 | nM | 8.94 |
| CHEMBL3770310 | — | IC50 | = | 2.291 | nM | 8.64 |
| CHEMBL284969 | — | IC50 | = | 11.22 | nM | 7.95 |
| CHEMBL116903 | — | IC50 | = | 27.54 | nM | 7.56 |
| CHEMBL3769641 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL3770679 | — | IC50 | = | 269.15 | nM | 6.57 |
| CHEMBL3771290 | — | pIC50 | - | — | - | |
| CHEMBL3771208 | — | pIC50 | - | — | - | |
| CHEMBL3770664 | — | pIC50 | - | — | - | |
| CHEMBL3771184 | — | pIC50 | - | — | - |