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Assay Detail

CHEMBL3773071

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiprotozoan activity against Toxoplasma gondii infected in fibroblasts assessed as growth inhibition after 44 hrs by beta-galactosidase reporter assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Toxoplasma gondii
Confidence 1 — Organism
Curated By Autocuration

Target

Toxoplasma gondii (CHEMBL612888)
Type ORGANISM
Organism Toxoplasma gondii

Publication

SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1.
Huang W, Ojo KK, Zhang Z, Rivas K, Vidadala RS, Scheele S, DeRocher AE, Choi R, Hulverson MA, Barrett LK, Bruzual I, Siddaramaiah LK, Kerchner KM, Kurnick MD, Freiberg GM, Kempf D, Hol WG, Merritt EA, Neckermann G, de Hostos EL, Isoherranen N, Maly DJ, Parsons M, Doggett JS, Van Voorhis WC, Fan E.
ACS Med Chem Lett (2015) 6 : 1184 -1189
PubMed 26693272 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 22 6.30 7.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3770299 1 7.05
CHEMBL3770142 1 6.85
CHEMBL3771306 1 6.70
CHEMBL3770980 1 6.68
CHEMBL3771104 1 6.50
CHEMBL3770760 1 6.48
CHEMBL3770425 1 6.40
CHEMBL3770649 1 6.39
CHEMBL3770313 1 6.38
CHEMBL3770802 1 6.37
CHEMBL3769798 1 6.32
CHEMBL3771134 1 6.32
CHEMBL3769990 1 6.32
CHEMBL3769685 1 6.28
CHEMBL3771242 1 6.16
CHEMBL3770409 1 6.14
CHEMBL3769623 1 6.01
CHEMBL3770743 1 5.92
CHEMBL3770546 1 5.92
CHEMBL3769940 1 5.92
CHEMBL3770076 1 5.83
CHEMBL3769459 1 5.65

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3770299 EC50 = 89.0 nM 7.05
CHEMBL3770142 EC50 = 140.0 nM 6.85
CHEMBL3771306 EC50 = 200.0 nM 6.70
CHEMBL3770980 EC50 = 210.0 nM 6.68
CHEMBL3771104 EC50 = 320.0 nM 6.50
CHEMBL3770760 EC50 = 330.0 nM 6.48
CHEMBL3770425 EC50 = 400.0 nM 6.40
CHEMBL3770649 EC50 = 410.0 nM 6.39
CHEMBL3770313 EC50 = 420.0 nM 6.38
CHEMBL3770802 EC50 = 430.0 nM 6.37
CHEMBL3769798 EC50 = 480.0 nM 6.32
CHEMBL3771134 EC50 = 480.0 nM 6.32
CHEMBL3769990 EC50 = 480.0 nM 6.32
CHEMBL3769685 EC50 = 520.0 nM 6.28
CHEMBL3771242 EC50 = 690.0 nM 6.16
CHEMBL3770409 EC50 = 720.0 nM 6.14
CHEMBL3769623 EC50 = 970.0 nM 6.01
CHEMBL3770743 EC50 = 1190.0 nM 5.92
CHEMBL3770546 EC50 = 1210.0 nM 5.92
CHEMBL3769940 EC50 = 1210.0 nM 5.92
CHEMBL3770076 EC50 = 1470.0 nM 5.83
CHEMBL3769459 EC50 = 2250.0 nM 5.65