Assay Detail
Binding
CHEMBL3773092
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Inhibition of NaCT in human hepatocytes assessed as [14C]-citrate uptake after 30 mins by scintillation counting method
16
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Hepatocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.80 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3770609 | — | — | 2 | 6.50 |
| CHEMBL3771118 | — | — | 2 | 6.13 |
| CHEMBL3769578 | — | — | 2 | 4.80 |
| CHEMBL3769514 | — | — | 1 | - |
| CHEMBL3770439 | — | — | 1 | - |
| CHEMBL3769911 | — | — | 1 | - |
| CHEMBL3770370 | — | — | 1 | - |
| CHEMBL3769920 | — | — | 1 | - |
| CHEMBL3769766 | — | — | 1 | - |
| CHEMBL3770497 | — | — | 1 | - |
| CHEMBL3771175 | — | — | 1 | - |
| CHEMBL3771155 | — | — | 1 | - |
| CHEMBL3770675 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3770609 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL3770609 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL3771118 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL3771118 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL3769578 | — | IC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL3769578 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL3769514 | — | IC50 | - | — | - | |
| CHEMBL3770439 | — | IC50 | - | — | - | |
| CHEMBL3769911 | — | IC50 | - | — | - | |
| CHEMBL3770370 | — | IC50 | - | — | - | |
| CHEMBL3769920 | — | IC50 | - | — | - | |
| CHEMBL3769766 | — | IC50 | - | — | - | |
| CHEMBL3770497 | — | IC50 | - | — | - | |
| CHEMBL3771175 | — | IC50 | - | — | - | |
| CHEMBL3771155 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3770675 | — | IC50 | - | — | - |