Assay Detail
Functional
CHEMBL3773517
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Antiplasmodial activity against liver stage Plasmodium berghei infected in Huh7 cells assessed as inhibition of parasite infection incubated for 1 hr prior to infection measured at 24 hrs by luciferase reporter gene assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium berghei |
| Tissue | Liver |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel squaramides with in vitro liver stage antiplasmodial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.54 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2435705 | — | — | 1 | 5.89 |
| CHEMBL2435706 | — | — | 1 | 5.89 |
| CHEMBL3771215 | — | — | 1 | 5.75 |
| CHEMBL3770988 | — | — | 1 | 5.66 |
| CHEMBL506 | PRIMAQUINE | 4.0 | 1 | 5.02 |
| CHEMBL3770139 | — | — | 1 | 5.00 |
| CHEMBL3770728 | — | — | 1 | - |
| CHEMBL3769947 | — | — | 1 | - |
| CHEMBL3770013 | — | — | 1 | - |
| CHEMBL3771283 | — | — | 1 | - |
| CHEMBL3771265 | — | — | 1 | - |
| CHEMBL3770634 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2435705 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2435706 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3771215 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3770988 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL506 | PRIMAQUINE | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL3770139 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3770728 | — | IC50 | - | — | - | |
| CHEMBL3769947 | — | IC50 | - | — | - | |
| CHEMBL3770013 | — | IC50 | - | — | - | |
| CHEMBL3771283 | — | IC50 | - | — | - | |
| CHEMBL3771265 | — | IC50 | - | — | - | |
| CHEMBL3770634 | — | IC50 | - | — | - |