Assay Detail
Binding
CHEMBL3773935
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Displacement of [3H]DTG from sigma-2 receptor in guinea pig brain membranes after 120 mins by liquid scintillation counting method
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures and derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 6.97 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3770485 | — | — | 1 | 8.38 |
| CHEMBL3770532 | — | — | 1 | 8.30 |
| CHEMBL3770830 | — | — | 1 | 8.20 |
| CHEMBL3769825 | — | — | 1 | 7.95 |
| CHEMBL3769895 | — | — | 1 | 7.79 |
| CHEMBL3769960 | — | — | 1 | 7.75 |
| CHEMBL3771017 | — | — | 1 | 7.75 |
| CHEMBL3769904 | — | — | 1 | 7.72 |
| CHEMBL178700 | — | — | 1 | 7.60 |
| CHEMBL359663 | — | — | 1 | 7.55 |
| CHEMBL3771186 | — | — | 1 | 7.55 |
| CHEMBL3769930 | — | — | 1 | 7.46 |
| CHEMBL3770762 | — | — | 1 | 7.11 |
| CHEMBL3771016 | — | — | 1 | 7.00 |
| CHEMBL3769508 | — | — | 1 | 6.84 |
| CHEMBL3770681 | — | — | 1 | 6.77 |
| CHEMBL3769801 | — | — | 1 | 6.69 |
| CHEMBL3770832 | — | — | 1 | 6.67 |
| CHEMBL3770072 | — | — | 1 | 6.65 |
| CHEMBL3770589 | — | — | 1 | 6.62 |
| CHEMBL3770593 | — | — | 1 | 6.56 |
| CHEMBL3769675 | — | — | 1 | 6.43 |
| CHEMBL3771163 | — | — | 1 | 5.66 |
| CHEMBL3770151 | — | — | 1 | 5.66 |
| CHEMBL3770871 | — | — | 1 | 5.64 |
| CHEMBL3769446 | — | — | 1 | 5.05 |
| CHEMBL3770992 | — | — | 1 | 4.90 |
| CHEMBL3769874 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3770485 | — | Ki | = | 4.169 | nM | 8.38 |
| CHEMBL3770532 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL3770830 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL3769825 | — | Ki | = | 11.22 | nM | 7.95 |
| CHEMBL3769895 | — | Ki | = | 16.22 | nM | 7.79 |
| CHEMBL3769960 | — | Ki | = | 17.78 | nM | 7.75 |
| CHEMBL3771017 | — | Ki | = | 17.78 | nM | 7.75 |
| CHEMBL3769904 | — | Ki | = | 19.05 | nM | 7.72 |
| CHEMBL178700 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL359663 | — | Ki | = | 28.18 | nM | 7.55 |
| CHEMBL3771186 | — | Ki | = | 28.18 | nM | 7.55 |
| CHEMBL3769930 | — | Ki | = | 34.67 | nM | 7.46 |
| CHEMBL3770762 | — | Ki | = | 77.62 | nM | 7.11 |
| CHEMBL3771016 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL3769508 | — | Ki | = | 144.54 | nM | 6.84 |
| CHEMBL3770681 | — | Ki | = | 169.82 | nM | 6.77 |
| CHEMBL3769801 | — | Ki | = | 204.17 | nM | 6.69 |
| CHEMBL3770832 | — | Ki | = | 213.8 | nM | 6.67 |
| CHEMBL3770072 | — | Ki | = | 223.87 | nM | 6.65 |
| CHEMBL3770589 | — | Ki | = | 239.88 | nM | 6.62 |
| CHEMBL3770593 | — | Ki | = | 275.42 | nM | 6.56 |
| CHEMBL3769675 | — | Ki | = | 371.54 | nM | 6.43 |
| CHEMBL3771163 | — | Ki | = | 2187.76 | nM | 5.66 |
| CHEMBL3770151 | — | Ki | = | 2187.76 | nM | 5.66 |
| CHEMBL3770871 | — | Ki | = | 2290.87 | nM | 5.64 |
| CHEMBL3769446 | — | Ki | = | 8912.51 | nM | 5.05 |
| CHEMBL3770992 | — | Ki | = | 12589.25 | nM | 4.90 |
| CHEMBL3769874 | — | Ki | > | 1000.0 | nM | - |