Assay Detail
Binding
CHEMBL3774067
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Escherichia coli lacZ beta-galactosidase using 4-nitrophenyl-beta-D-galactopyranoside as substrate preincubated up to 5 mins followed by substrate addition measured up to 10 mins
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of C-5a-chain extended derivatives of 4-epi-isofagomine: Powerful β-galactosidase inhibitors and low concentration activators of GM1-gangliosidosis-related human lysosomal β-galactosidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.48 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3771185 | — | — | 1 | 8.54 |
| CHEMBL1818433 | — | — | 1 | 7.51 |
| CHEMBL3770764 | — | — | 1 | 7.31 |
| CHEMBL3770736 | — | — | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3771185 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL1818433 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL3770764 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL3770736 | — | Ki | = | 280.0 | nM | 6.55 |