Assay Detail
Binding
CHEMBL3774068
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine liver beta-galactosidase using 4-nitrophenyl-beta-D-galactopyranoside as substrate preincubated up to 5 mins followed by substrate addition measured up to 10 mins
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of C-5a-chain extended derivatives of 4-epi-isofagomine: Powerful β-galactosidase inhibitors and low concentration activators of GM1-gangliosidosis-related human lysosomal β-galactosidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.84 | 7.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3771185 | — | — | 1 | 7.90 |
| CHEMBL3770764 | — | — | 1 | 5.40 |
| CHEMBL3770736 | — | — | 1 | 5.05 |
| CHEMBL1818433 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3771185 | — | Ki | = | 12.7 | nM | 7.90 |
| CHEMBL3770764 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL3770736 | — | Ki | = | 8940.0 | nM | 5.05 |
| CHEMBL1818433 | — | Ki | = | 10000.0 | nM | 5.00 |