Assay Detail
Binding
CHEMBL3776337
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of KDM3A (unknown origin) expressed in Escherichia coli using H3 (1 to 21 residues) K9Me2-GGK-Biotin KDM3A Cognate Ligand/10 uM alpha-ketoglutarate as substrate/cofactor preincubated for 5 mins followed by substrate addition measured after 20 mins by alphascreen assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.14 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3775262 | — | — | 1 | 5.64 |
| CHEMBL316034 | — | — | 1 | 5.48 |
| CHEMBL3775867 | — | — | 1 | 5.24 |
| CHEMBL3775272 | — | — | 1 | 5.05 |
| CHEMBL3775380 | — | — | 1 | 4.96 |
| CHEMBL3774598 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3775262 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL316034 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3775867 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL3775272 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL3775380 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3774598 | — | IC50 | = | 33000.0 | nM | 4.48 |