Assay Detail
Binding
CHEMBL3777370
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CE1 in human liver microsomes using 2-(2-Benzoyl-3-methoxyphenyl) benzothiazole as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins by LC-UV analysis
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and structure-activity relationship study of glycyrrhetinic acid derivatives as potent and selective inhibitors against human carboxylesterase 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.96 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1231178 | — | — | 1 | 6.85 |
| CHEMBL1551302 | BAVACHININ A | — | 1 | 5.46 |
| CHEMBL3775916 | — | — | 1 | 5.16 |
| CHEMBL3775391 | — | — | 1 | 5.04 |
| CHEMBL487933 | — | — | 1 | 4.98 |
| CHEMBL1271200 | — | — | 1 | 4.96 |
| CHEMBL3775320 | — | — | 1 | 4.91 |
| CHEMBL3774603 | — | — | 1 | 4.69 |
| CHEMBL230006 | ENOXOLONE | 2.0 | 1 | 4.68 |
| CHEMBL1271483 | — | — | 1 | 4.65 |
| CHEMBL3775913 | — | — | 1 | 4.63 |
| CHEMBL3775118 | — | — | 1 | 4.60 |
| CHEMBL1271536 | — | — | 1 | 4.58 |
| CHEMBL207413 | ACETOXOLONE | -1.0 | 1 | 4.30 |
| CHEMBL3775481 | — | — | 1 | - |
| CHEMBL2151605 | — | — | 1 | - |
| CHEMBL493512 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1231178 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1551302 | BAVACHININ A | IC50 | = | 3470.0 | nM | 5.46 |
| CHEMBL3775916 | — | IC50 | = | 6990.0 | nM | 5.16 |
| CHEMBL3775391 | — | IC50 | = | 9130.0 | nM | 5.04 |
| CHEMBL487933 | — | IC50 | = | 10530.0 | nM | 4.98 |
| CHEMBL1271200 | — | IC50 | = | 10970.0 | nM | 4.96 |
| CHEMBL3775320 | — | IC50 | = | 12310.0 | nM | 4.91 |
| CHEMBL3774603 | — | IC50 | = | 20410.0 | nM | 4.69 |
| CHEMBL230006 | ENOXOLONE | IC50 | = | 20970.0 | nM | 4.68 |
| CHEMBL1271483 | — | IC50 | = | 22360.0 | nM | 4.65 |
| CHEMBL3775913 | — | IC50 | = | 23610.0 | nM | 4.63 |
| CHEMBL3775118 | — | IC50 | = | 25090.0 | nM | 4.60 |
| CHEMBL1271536 | — | IC50 | = | 26260.0 | nM | 4.58 |
| CHEMBL207413 | ACETOXOLONE | IC50 | = | 49860.0 | nM | 4.30 |
| CHEMBL3775481 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2151605 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL493512 | — | IC50 | > | 100000.0 | nM | - |