Assay Detail
Binding
CHEMBL3777632
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at HA-epitope tagged GRP55E expressed with GFP-tagged beta-arr2 in human U2OS cells assessed as LPI-stimulated redistribution of beta-arr2 preincubated for 15 mins by beta-arrestin translocation assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and analysis of antagonists of GPR55: Piperidine-substituted 1,3,4-oxadiazol-2-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.26 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1310336 | — | — | 1 | 6.66 |
| CHEMBL1402920 | — | — | 1 | 6.16 |
| CHEMBL1366039 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1310336 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1402920 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1366039 | — | IC50 | = | 1100.0 | nM | 5.96 |