Assay Detail
Functional
CHEMBL3777640
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Natural product-based design, synthesis and biological evaluation of Albiziabioside A derivatives that selectively induce HCT116 cell death.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.65 | 4.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1765593 | — | — | 1 | 4.99 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.31 |
| CHEMBL3775299 | — | — | 1 | - |
| CHEMBL3774443 | — | — | 1 | - |
| CHEMBL3774974 | — | — | 1 | - |
| CHEMBL3775078 | — | — | 1 | - |
| CHEMBL3774977 | — | — | 1 | - |
| CHEMBL3775595 | — | — | 1 | - |
| CHEMBL3774860 | — | — | 1 | - |
| CHEMBL3775374 | — | — | 1 | - |
| CHEMBL3775642 | — | — | 1 | - |
| CHEMBL3775927 | — | — | 1 | - |
| CHEMBL3775139 | — | — | 1 | - |
| CHEMBL3774460 | — | — | 1 | - |
| CHEMBL3775855 | — | — | 1 | - |
| CHEMBL3775325 | — | — | 1 | - |
| CHEMBL3775738 | — | — | 1 | - |
| CHEMBL3775469 | — | — | 1 | - |
| CHEMBL3775919 | — | — | 1 | - |
| CHEMBL3774558 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1765593 | — | IC50 | = | 10280.0 | nM | 4.99 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 49020.0 | nM | 4.31 |
| CHEMBL3775299 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3774443 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3774974 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3775078 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3774977 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3775595 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3774860 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3775374 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3775642 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3775927 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3775139 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3774460 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3775855 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3775325 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3775738 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3775469 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3775919 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3774558 | — | IC50 | > | 50000.0 | nM | - |