Assay Detail
Binding
CHEMBL3777660
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Inhibition of CDK9 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
5-Substituted 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidines with anti-proliferative activity as potent and selective inhibitors of cyclin-dependent kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.27 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2103840 | DINACICLIB | 3.0 | 1 | 6.75 |
| CHEMBL3774632 | — | — | 1 | 6.62 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 6.05 |
| CHEMBL1801932 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2103840 | DINACICLIB | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL3774632 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 892.0 | nM | 6.05 |
| CHEMBL1801932 | — | IC50 | = | 2180.0 | nM | 5.66 |