Assay Detail
Binding
CHEMBL3777826
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125ITyr0-Glu1]-PD-Svg in mouse CRF-R2 beta expressed in COS-M6 cells after 90 mins by gamma counting assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | COS-M6 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Corticotropin-releasing factor receptor 2 (CHEMBL2253) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Characterization of Multisubstituted Corticotropin Releasing Factor (CRF) Peptide Antagonists (Astressins).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 9.29 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3774395 | — | — | 1 | 9.59 |
| CHEMBL3774465 | — | — | 1 | 9.54 |
| CHEMBL3774742 | — | — | 1 | 9.49 |
| CHEMBL3775796 | — | — | 1 | 9.44 |
| CHEMBL4299355 | — | — | 1 | 9.02 |
| CHEMBL4299313 | — | — | 1 | 8.97 |
| CHEMBL4299340 | — | — | 1 | 8.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3774395 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL3774465 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL3774742 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL3775796 | — | Ki | = | 0.36 | nM | 9.44 |
| CHEMBL4299355 | — | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL4299313 | — | Ki | = | 1.07 | nM | 8.97 |
| CHEMBL4299340 | — | Ki | = | 1.07 | nM | 8.97 |