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Assay Detail

CHEMBL3778084

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant full length p300 (unknown origin) using N-terminal H4-20 peptide substrate incubated for 7 mins by radiometric gel assay in presence of [14C]acetyl-CoA
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Histone acetyltransferase p300 (CHEMBL3784)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

KATching-Up on Small Molecule Modulators of Lysine Acetyltransferases.
Simon RP, Robaa D, Alhalabi Z, Sippl W, Jung M.
J Med Chem (2016) 59 : 1249 -1270
PubMed 26701186 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 7.30 7.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL505121 1 7.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL505121 IC50 = 50.0 nM 7.30