Assay Detail
Binding
CHEMBL3778467
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Inhibition of COX-2 (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of [(125)I]Pyricoxib: A novel (125)I-labeled cyclooxygenase-2 (COX-2) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.09 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 7.40 |
| CHEMBL404108 | LUMIRACOXIB | 4.0 | 1 | 7.22 |
| CHEMBL274990 | SC-58125 | — | 1 | 5.96 |
| CHEMBL3775406 | — | — | 1 | 5.60 |
| CHEMBL1672583 | — | — | 1 | 5.28 |
| CHEMBL3775974 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL404108 | LUMIRACOXIB | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL274990 | SC-58125 | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3775406 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1672583 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3775974 | — | IC50 | = | 8200.0 | nM | 5.09 |