Assay Detail
Binding
CHEMBL3778474
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 125I-[Sar1, Ile8] AngII from rat AT1 receptor expressed in COS1 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | COS-1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Tactical Approaches to Interconverting GPCR Agonists and Antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 8.19 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3775463 | — | — | 1 | 9.10 |
| CHEMBL1516 | OLMESARTAN | 3.0 | 1 | 8.64 |
| CHEMBL3775948 | — | — | 1 | 7.68 |
| CHEMBL3774865 | — | — | 1 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3775463 | — | Kd | = | 0.8 | nM | 9.10 |
| CHEMBL1516 | OLMESARTAN | Kd | = | 2.3 | nM | 8.64 |
| CHEMBL3775948 | — | Kd | = | 21.0 | nM | 7.68 |
| CHEMBL3774865 | — | Kd | = | 48.0 | nM | 7.32 |