Assay Detail
Binding
CHEMBL3778477
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Inhibition of human recombinant HDAC8 using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysis
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Selective Histone Deacetylase 6 Inhibitors Using the Quinazoline as the Cap for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.96 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 8.30 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.76 |
| CHEMBL2364628 | RICOLINOSTAT | 2.0 | 1 | 6.59 |
| CHEMBL3775072 | — | — | 1 | 6.00 |
| CHEMBL3774993 | — | — | 1 | 5.98 |
| CHEMBL3775521 | — | — | 1 | 5.93 |
| CHEMBL3774858 | — | — | 1 | 5.88 |
| CHEMBL3774793 | — | — | 1 | 5.85 |
| CHEMBL3775662 | — | — | 1 | 5.83 |
| CHEMBL3774890 | — | — | 1 | 5.82 |
| CHEMBL3775409 | — | — | 1 | 5.82 |
| CHEMBL3775817 | — | — | 1 | 5.77 |
| CHEMBL3774691 | — | — | 1 | 5.70 |
| CHEMBL3775209 | — | — | 1 | 5.61 |
| CHEMBL3775581 | — | — | 1 | 5.53 |
| CHEMBL3774414 | — | — | 1 | 5.47 |
| CHEMBL3775654 | — | — | 1 | 5.29 |
| CHEMBL3775269 | — | — | 1 | 5.21 |
| CHEMBL3774413 | — | — | 1 | - |
| CHEMBL3775009 | — | — | 1 | - |
| CHEMBL3774994 | — | — | 1 | - |
| CHEMBL3775539 | — | — | 1 | - |
| CHEMBL3774877 | — | — | 1 | - |
| CHEMBL3775457 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483254 | PANOBINOSTAT | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL2364628 | RICOLINOSTAT | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL3775072 | — | IC50 | = | 1003.0 | nM | 6.00 |
| CHEMBL3774993 | — | IC50 | = | 1058.0 | nM | 5.98 |
| CHEMBL3775521 | — | IC50 | = | 1181.0 | nM | 5.93 |
| CHEMBL3774858 | — | IC50 | = | 1326.0 | nM | 5.88 |
| CHEMBL3774793 | — | IC50 | = | 1422.0 | nM | 5.85 |
| CHEMBL3775662 | — | IC50 | = | 1465.0 | nM | 5.83 |
| CHEMBL3774890 | — | IC50 | = | 1531.0 | nM | 5.82 |
| CHEMBL3775409 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL3775817 | — | IC50 | = | 1698.0 | nM | 5.77 |
| CHEMBL3774691 | — | IC50 | = | 1987.0 | nM | 5.70 |
| CHEMBL3775209 | — | IC50 | = | 2457.0 | nM | 5.61 |
| CHEMBL3775581 | — | IC50 | = | 2974.0 | nM | 5.53 |
| CHEMBL3774414 | — | IC50 | = | 3398.0 | nM | 5.47 |
| CHEMBL3775654 | — | IC50 | = | 5189.0 | nM | 5.29 |
| CHEMBL3775269 | — | IC50 | = | 6190.0 | nM | 5.21 |
| CHEMBL3774413 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3775009 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3774994 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3775539 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3774877 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3775457 | — | IC50 | > | 1000.0 | nM | - |