Assay Detail
Functional
CHEMBL3778481
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of histone H3 acetylation in human HeLa cells incubated for 6 hrs by cytoblot assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Selective Histone Deacetylase 6 Inhibitors Using the Quinazoline as the Cap for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.94 | 6.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3775521 | — | — | 1 | 6.34 |
| CHEMBL3774793 | — | — | 1 | 5.90 |
| CHEMBL3774414 | — | — | 1 | 5.76 |
| CHEMBL3775581 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3775521 | — | EC50 | = | 456.5 | nM | 6.34 |
| CHEMBL3774793 | — | EC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL3774414 | — | EC50 | = | 1741.0 | nM | 5.76 |
| CHEMBL3775581 | — | EC50 | = | 1767.0 | nM | 5.75 |