Assay Detail
Binding
CHEMBL3778935
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125ITyr0-Glu1,Nle17]-PS-Svg in mouse CRF-R2 beta expressed in COS-M6 cells after 90 mins by gamma counting assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | COS-M6 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Corticotropin-releasing factor receptor 2 (CHEMBL2253) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Characterization of Multisubstituted Corticotropin Releasing Factor (CRF) Peptide Antagonists (Astressins).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 9.05 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4299341 | — | — | 1 | 9.77 |
| CHEMBL4299340 | — | — | 1 | 9.77 |
| CHEMBL3775778 | — | — | 1 | 9.66 |
| CHEMBL3775192 | — | — | 1 | 9.49 |
| CHEMBL4299294 | — | — | 1 | 9.48 |
| CHEMBL4299295 | — | — | 1 | 9.46 |
| CHEMBL3774465 | — | — | 1 | 9.46 |
| CHEMBL3774742 | — | — | 1 | 9.43 |
| CHEMBL3774395 | — | — | 1 | 9.43 |
| CHEMBL3774939 | — | — | 1 | 9.42 |
| CHEMBL3775761 | — | — | 1 | 9.41 |
| CHEMBL4299297 | — | — | 1 | 9.40 |
| CHEMBL3774868 | — | — | 1 | 9.36 |
| CHEMBL4299349 | — | — | 1 | 9.34 |
| CHEMBL4299308 | — | — | 1 | 9.26 |
| CHEMBL4299314 | — | — | 1 | 9.26 |
| CHEMBL4299348 | — | — | 1 | 9.22 |
| CHEMBL3774836 | — | — | 1 | 9.21 |
| CHEMBL3775678 | — | — | 1 | 9.21 |
| CHEMBL3774485 | — | — | 1 | 9.10 |
| CHEMBL4299355 | — | — | 1 | 9.09 |
| CHEMBL3775437 | — | — | 1 | 9.07 |
| CHEMBL4299335 | — | — | 1 | 9.05 |
| CHEMBL4299352 | — | — | 1 | 9.04 |
| CHEMBL3775796 | — | — | 1 | 9.03 |
| CHEMBL3775812 | — | — | 1 | 9.00 |
| CHEMBL4299286 | — | — | 1 | 8.91 |
| CHEMBL3775621 | — | — | 1 | 8.70 |
| CHEMBL3775030 | — | — | 1 | 8.70 |
| CHEMBL4299287 | — | — | 1 | 8.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4299341 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL4299340 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL3775778 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL3775192 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL4299294 | — | Ki | = | 0.33 | nM | 9.48 |
| CHEMBL4299295 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL3774465 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL3774742 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL3774395 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL3774939 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL3775761 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL4299297 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL3774868 | — | Ki | = | 0.44 | nM | 9.36 |
| CHEMBL4299349 | — | Ki | = | 0.46 | nM | 9.34 |
| CHEMBL4299314 | — | Ki | = | 0.55 | nM | 9.26 |
| CHEMBL4299308 | — | Ki | = | 0.55 | nM | 9.26 |
| CHEMBL4299348 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL3775678 | — | Ki | = | 0.62 | nM | 9.21 |
| CHEMBL3774836 | — | Ki | = | 0.62 | nM | 9.21 |
| CHEMBL3774485 | — | Ki | = | 0.79 | nM | 9.10 |
| CHEMBL4299355 | — | Ki | = | 0.81 | nM | 9.09 |
| CHEMBL3775437 | — | Ki | = | 0.86 | nM | 9.07 |
| CHEMBL4299335 | — | Ki | = | 0.89 | nM | 9.05 |
| CHEMBL4299352 | — | Ki | = | 0.92 | nM | 9.04 |
| CHEMBL3775796 | — | Ki | = | 0.94 | nM | 9.03 |
| CHEMBL3775812 | — | Ki | = | 0.99 | nM | 9.00 |
| CHEMBL4299286 | — | Ki | = | 1.23 | nM | 8.91 |
| CHEMBL3775621 | — | Ki | = | 2.02 | nM | 8.70 |
| CHEMBL3775030 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4299287 | — | Ki | = | 2.03 | nM | 8.69 |
| CHEMBL4299313 | — | Ki | = | 2.11 | nM | 8.68 |
| CHEMBL3774713 | — | Ki | = | 2.16 | nM | 8.67 |
| CHEMBL3774682 | — | Ki | = | 2.39 | nM | 8.62 |
| CHEMBL3774594 | — | Ki | = | 4.02 | nM | 8.40 |
| CHEMBL3775830 | — | Ki | = | 4.03 | nM | 8.39 |
| CHEMBL3775707 | — | Ki | = | 40.72 | nM | 7.39 |
| CHEMBL3775831 | — | Ki | = | 46.18 | nM | 7.34 |