Assay Detail
Binding
CHEMBL3779092
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Binding affinity to biotin labelled 5'-CATATATATCCCCATATATATG-3' hairpin dsDNA (unknown origin) immobilized on biosensor chip by surface plasmon resonance analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Bisimidazoline arylamides binding to the DNA minor groove: N1-hydroxylation enhances binding affinity and selectivity to AATT sites
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 5.88 | 6.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3775909 | — | — | 1 | 6.56 |
| CHEMBL534524 | — | — | 1 | 6.51 |
| CHEMBL3774812 | — | — | 1 | 6.46 |
| CHEMBL3774924 | — | — | 1 | 5.75 |
| CHEMBL3774997 | — | — | 1 | 5.40 |
| CHEMBL429921 | — | — | 1 | 5.36 |
| CHEMBL534122 | — | — | 1 | 5.09 |
| CHEMBL3774731 | — | — | 1 | - |
| CHEMBL3304498 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3775909 | — | Kd | = | 273.0 | nM | 6.56 |
| CHEMBL534524 | — | Kd | = | 307.0 | nM | 6.51 |
| CHEMBL3774812 | — | Kd | = | 351.0 | nM | 6.46 |
| CHEMBL3774924 | — | Kd | = | 1790.0 | nM | 5.75 |
| CHEMBL3774997 | — | Kd | = | 4000.0 | nM | 5.40 |
| CHEMBL429921 | — | Kd | = | 4350.0 | nM | 5.36 |
| CHEMBL534122 | — | Kd | = | 8060.0 | nM | 5.09 |
| CHEMBL3774731 | — | Kd | > | 29000.0 | nM | - |
| CHEMBL3304498 | — | Kd | > | 29000.0 | nM | - |