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Assay Detail

CHEMBL3779093

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to biotin labelled 5'-CGCGCGCGTTTTCGCGCGCG-3' hairpin dsDNA (unknown origin) immobilized on biosensor chip by surface plasmon resonance analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Bisimidazoline arylamides binding to the DNA minor groove: N1-hydroxylation enhances binding affinity and selectivity to AATT sites
Rios Martinez CH, Lagartera L, Trujillo C, Dardonville C
Medchemcomm (2015) 6 : 2036 -2042
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 13 4.43 4.73

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3775909 1 4.73
CHEMBL429921 1 4.71
CHEMBL3774924 1 4.18
CHEMBL3774997 1 4.11
CHEMBL3775314 1 -
CHEMBL3774731 1 -
CHEMBL3304498 1 -
CHEMBL534122 1 -
CHEMBL3303970 1 -
CHEMBL3302053 1 -
CHEMBL535671 1 -
CHEMBL3774812 1 -
CHEMBL534524 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3775909 Kd = 18500.0 nM 4.73
CHEMBL429921 Kd = 19600.0 nM 4.71
CHEMBL3774924 Kd = 66700.0 nM 4.18
CHEMBL3774997 Kd = 76900.0 nM 4.11
CHEMBL3775314 Kd - -
CHEMBL3774731 Kd > 29000.0 nM -
CHEMBL3304498 Kd - -
CHEMBL534122 Kd = 158700.0 nM -
CHEMBL3303970 Kd > 10000.0 nM -
CHEMBL3302053 Kd > 10000.0 nM -
CHEMBL535671 Kd > 10000.0 nM -
CHEMBL3774812 Kd > 10000.0 nM -
CHEMBL534524 Kd > 10000.0 nM -