Assay Detail
Binding
CHEMBL3779451
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Inhibition of recombinant human COX2 assessed as production of PGF2-alpha preincubated with compound followed by the addition of 5 uM arachidonic acid as substrate by enzyme immunoassay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 5.83 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3774784 | — | — | 1 | 7.30 |
| CHEMBL3775104 | — | — | 1 | 6.80 |
| CHEMBL3774442 | — | — | 1 | 6.77 |
| CHEMBL3775510 | — | — | 1 | 6.70 |
| CHEMBL3775770 | — | — | 1 | 6.62 |
| CHEMBL3775979 | — | — | 1 | 6.50 |
| CHEMBL3775041 | — | — | 1 | 6.37 |
| CHEMBL3775653 | — | — | 1 | 6.25 |
| CHEMBL3774686 | — | — | 1 | 6.16 |
| CHEMBL3774941 | — | — | 1 | 6.14 |
| CHEMBL3775430 | — | — | 1 | 6.03 |
| CHEMBL563 | FLURBIPROFEN | 4.0 | 1 | 5.97 |
| CHEMBL3774833 | — | — | 1 | 5.85 |
| CHEMBL3774754 | — | — | 1 | 5.57 |
| CHEMBL3774586 | — | — | 1 | 5.21 |
| CHEMBL3774467 | — | — | 1 | 4.97 |
| CHEMBL3775528 | — | — | 1 | 4.92 |
| CHEMBL3775676 | — | — | 1 | 4.89 |
| CHEMBL3774706 | — | — | 1 | 4.64 |
| CHEMBL3774873 | — | — | 1 | 4.54 |
| CHEMBL3774572 | — | — | 1 | 4.13 |
| CHEMBL3775699 | — | — | 1 | - |
| CHEMBL3774541 | — | — | 1 | - |
| CHEMBL3774781 | — | — | 1 | - |
| CHEMBL3774867 | — | — | 1 | - |
| CHEMBL3775462 | — | — | 1 | - |
| CHEMBL3775392 | — | — | 1 | - |
| CHEMBL3775973 | — | — | 1 | - |
| CHEMBL3774999 | — | — | 1 | - |
| CHEMBL3774393 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3774784 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3775104 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3774442 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3775510 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3775770 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3775979 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3775041 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL3775653 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL3774686 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3774941 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL3775430 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL563 | FLURBIPROFEN | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL3774833 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3774754 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL3774586 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL3774467 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL3775528 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL3775676 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3774706 | — | IC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL3774873 | — | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL3774572 | — | IC50 | = | 74300.0 | nM | 4.13 |
| CHEMBL3774876 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3774439 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3774618 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL184238 | URB-597 | IC50 | > | 100000.0 | nM | - |
| CHEMBL3775610 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3775475 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3774805 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3775954 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3775360 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3775280 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3775699 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3774393 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3774999 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3775973 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3775392 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3775462 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3774867 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3774781 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3774541 | — | IC50 | > | 100000.0 | nM | - |